Hypercholesterolaemia and Liver Enlargement in Experimental Hepatic Porphyria

Ultrastructural study of the liver in hepatic porphyria

SYNOPSIS In intermittent acute porphyria there are no specific alterations in the ultrastructure of the liver. In contrast, the constant characteristic of porphyria cutanea tarda is siderosis of the hepatocytes and Kupffer cells. Therefore, between the two types of hepatic porphyria there are no similar ultrastructural lesions. It is still doubtfulwhether the presence of hepatosiderosis in porp...

Experimental hepatic porphyria caused by feeding 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine. Comparison with sedormid porphyria.

Since Schmid & Schwartz (1952) described an experimental hepatic porphyria induced in rabbits by Sedormid (2-isopropylpent-4-enoylurea), several drugs chemically related to Sedormid (Goldberg & Rimington, 1955; Stich & Decker, 1955a, b; Talman, Labbe & Aldrich, 1957) and some barbiturates (Goldberg, 1954a) have been shown to cause excretion of both porphobilinogen and porphyrins in animals. Gol...

Acute Hepatic Porphyria

The porphyrias comprise a set of diseases, each representing an individual defect in one of the eight enzymes mediating the pathway of heme synthesis. The diseases are genetically distinct but have in common the overproduction of heme precursors. In the case of the acute (neurologic) porphyrias, the cause of symptoms appears to be overproduction of a neurotoxic precursor. For the cutaneous porp...

Cutaneous hepatic porphyria and oestrogens.

Symptomatic Cutaneous Hepatic Porphyria and from Rats with Porphyria

1. Three tetracarboxylate porphyrins, apart from coproporphyrin, were isolated from the faeces of patients with symptomatic cutaneous hepatic porphyria and of rats with porphyria caused by hexachlorobenzene poisoning. The porphyrins were not present in the urine of the porphyric rats or in the faeces of control rats. 2. Two of the porphyrins were identified as tris-(2-carboxyethyl)-carboxymethy...